Article

Substructure and maturation of lamina-associated domains in neurons of the developing and adult human brain

2024-11-28

Abstract excerpt

<h4>Summary</h4> Approximately 30-40% of the human genome is anchored to the nuclear lamina (NL) through variably sized (10 kb-10 Mb) lamina-associated domains (LADs), which can be classified into two subtypes (T1 and T2) based on their level of lamina-association. The dynamics of LAD substructure in cells that remain postmitotic for long periods of time are poorly understood. Here, we developed Genome Organizati...

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Literature Corpus work: f2cc16be-f813-5cc9-90d2-5063b724f9dc
DOI: 10.1101/2024.11.27.625786

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