Article

SWING regions prime chromatin for nuclear speckle–mediated gene regulation

2025-10-03

Abstract excerpt

Nuclear speckles have long been recognized as RNA-rich nuclear bodies, yet their role in genome organization and gene regulation remains incompletely understood. Using a rapid dTAG-mediated degradation system to simultaneously deplete SON and SRRM2—the core structural components of nuclear speckles—we identify a novel class of genomic regions, which we term SWING regions. Upon speckle disruption, SWING regions rel...

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Literature Corpus work: e5c3a902-db68-55b4-95b9-05c118deaf45
DOI: 10.1101/2025.10.01.679801

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