Article

From compartments to gene loops: Functions of the 3D genome in the human brain

2021-10-14

Abstract excerpt

The 3D genome plays a key role in the regulation of gene expression. However, little is known about the spatiotemporal organization of chromatin during human brain development. We investigated the 3D genome in human fetal cortical plate and in adult prefrontal cortical neurons and glia. We found that neurons have weaker compartments than glia that emerge during fetal development. Furthermore, neurons form loop dom...

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Literature Corpus work: 84fbec91-1068-5b96-9018-380a5ba391c8
DOI: 10.1101/2021.10.12.464094

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