Article

Nucleolus and centromere TSA-Seq reveals variable localization of heterochromatin in different cell types

2023-11-01

Abstract excerpt

Genome differential positioning within interphase nuclei remains poorly explored. We extended and validated TSA-seq to map genomic regions near nucleoli and pericentric heterochromatin in four human cell lines. Our study confirmed that smaller chromosomes localize closer to nucleoli but further deconvolved this by revealing a preference for chromosome arms below 36-46 Mbp in length. We identified two lamina associ...

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Literature Corpus work: e77c20ef-d70a-508a-9e1d-aeb310fb7e88
DOI: 10.1101/2023.10.29.564613

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