NSD3 stabilizes nuclear compartmentalization and promotes megabase-scale chromatin interactions

Abstract excerpt

<h4>ABSTRACT</h4> Identifying biomolecules that shape nuclear organization is essential for understanding gene regulation in health and disease. Oncogenic fusion proteins rewire chromosome folding and generate biomolecular condensates, but the cofactors of oncoprotein-driven chromatin regulation remain poorly defined, and whether such factors have analogous functions in fusion-naïve cells is unknown. We find that...

Topics

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• Binding Sites
• Methylation
• Models, Molecular
• Mutation
• Neoplasm Transplantation
• Neoplasms
• Nuclear Proteins
• Phenotype

Identifiers and source

Literature Corpus work

88b1c0d8-12fc-5db5-8fc4-ddbeabc829fd

DOI

10.64898/2026.02.07.704091