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Article

Structural basis underlying viral hijacking of a histone chaperone complex

1 Sept 2016

Abstract excerpt

The histone H3.3 chaperone DAXX is implicated in formation of heterochromatin and transcription silencing, especially for newly infecting DNA virus genomes entering the nucleus. Epstein-Barr virus (EBV) can efficiently establish stable latent infection as a chromatinized episome in the nucleus of infected cells. The EBV tegument BNRF1 is a DAXX-interacting protein required for the establishment of selective viral...

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PMID: 27581705
DOI: 10.1038/ncomms12707

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