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Article

Evolutionary development of redundant nuclear localization signals in the mRNA export factor NXF1.

Molecular biology of the cell - 1 Dec 2011

Zhang Zi Chao, Satterly Neal, Fontoura Beatriz M A, Chook Yuh Min

Abstract excerpt

In human cells, the mRNA export factor NXF1 resides in the nucleoplasm and at nuclear pore complexes. Karyopherin β2 or transportin recognizes a proline-tyrosine nuclear localization signal (PY-NLS) in the N-terminal tail of NXF1 and imports it into the nucleus. Here biochemical and cellular studies to understand the energetic organization of the NXF1 PY-NLS reveal unexpected redundancy in the nuclear import...

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Identifiers

PMID: 21965294
DOI: 10.1091/mbc.E11-03-0222
PMCID: PMC3226482

Genes

NXF1

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