Article

Soluble Syntaxin 3 Functions as a Transcription Regulator

2017-07-13

Abstract excerpt

<h4>SUMMARY</h4> Syntaxins - a conserved family of SNARE proteins - contain C-terminal transmembrane anchors required for their membrane fusion activity. Here we show that syntaxin 3 (Stx3) unexpectedly also functions as a nuclear regulator of gene expression. Alternative splicing leads to a soluble isoform, termed Stx3S, lacking the transmembrane anchor. Soluble Stx3S binds to the nuclear import factor RanBP5, t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ca3e3611-8d85-551c-8501-b93ce8466713
DOI: 10.1101/162958

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Soluble Syntaxin 3 Functions as a Transcription RegulatorDOI 10.1101/162958Read

STAT3 nuclear import is independent of tyrosine phosphorylation and mediated by importin-α3Semantic proximity Read

ALS Associated Mutations in Matrin 3 Alter Protein-Protein Interactions and Impede mRNA Nuclear Export.Semantic proximity Read

Dynamic Trafficking of STAT5 Depends on an Unconventional Nuclear Localization SignalSemantic proximity Read

Importins recognize the winged-helix fold of ETS transcription factors to mediate nuclear importSemantic proximity Read

Gene Expression Responses to FUS, EWS, and TAF15 Reduction and Stress Granule Sequestration Analyses Identifies FET-Protein Non-Redundant FunctionsSemantic proximity Read

Role of SYT11 in human pan-cancer using comprehensive approachesSemantic proximity Read

Syntaxin-3 regulates Tight Junction Assembly in Human Retinal Pigment EpitheliumSemantic proximity Read

METTL3 regulates exocytosis independently of m <sup>6</sup> ASemantic proximity Read

TOX3 is expressed in mammary ER+ epithelial cells and regulates ER target genes in luminal breast cancerSemantic proximity Read

TBX3 regulates splicing in vivo: a novel molecular mechanism for Ulnar-mammary syndrome.Semantic proximity Read

Mutations in GET4 disrupt the transmembrane domain recognition complex pathway.Semantic proximity Read

X-linked hypoparathyroidism region on Xq27 is evolutionarily conserved with regions on 3q26 and 13q34 and contains a novel P-type ATPase.Semantic proximity Read