Article

The HIV-1 Nuclear Export Complex Reveals the Role of RNA in Crm1 Cargo Recognition

2024-09-22

Abstract excerpt

Crm1 is a highly conserved nuclear exportin that transports >1000 human proteins including ribonucleoprotein (RNP) complexes. The interface between Crm1 and RNP cargos is unknown. The HIV regulatory protein, Rev, was one of the first identified cargos for Crm1 and contains a prototypic nuclear export sequence (NES). We present the cryo-electron microscopy structure of the HIV-1 nuclear export complex (Crm1/Ran-GTP...

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Literature Corpus work: a5b85be5-4b74-524d-8080-e4127bad62b4
DOI: 10.1101/2024.09.22.614349

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