Article

A bipartite, mutation-tolerant NLS regulates interaction of ΔNp63α with importin alpha, nuclear transport and transcriptional activity

2025-06-15

Abstract excerpt

<h4>ABSTRACT</h4> ΔNp63α is a master regulator of epithelial development, driving the expansion of progenitor cells in stratified epithelia. Mutations in ΔNp63α are linked to squamous cell carcinomas (SCCs) and basal cell carcinomas (BCCs), as well as to ectodermal dysplasia syndromes such as ectrodactyly-ectodermal dysplasia-clefting (EEC) and ankyloblepharon-ectodermal dysplasia-clefting (AEC). Although ΔNp63α...

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Literature Corpus work: d7a7d7ab-760b-53a6-b592-d81363afa1d9
DOI: 10.1101/2025.06.12.659319

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