Article

Multidomain Coupling Governs FoxP1 Assembly and Nuclear Compartmentalization

2026-06-04

Abstract excerpt

<h4>SUMMARY</h4> FoxP1 is a multidomain transcription factor implicated in development, immunity, and cancer, widely proposed to function as a dimer. However, the molecular mechanisms governing its assembly and nuclear organization in living cells remain unclear. Here, we combine biochemical assays and live-cell fluorescence lifetime imaging to resolve FoxP1 homotypic interactions. We show that FoxP1 forms hetero...

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Literature Corpus work: 6aa6759f-a3dd-5b98-9cf2-55f6a5560309
DOI: 10.64898/2026.06.02.728184

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