Article

Cascade-targeting strategy with UTMD for noninvasive transendothelial delivery of TBK1-PROTAC for enhancing anti-inflammatory efficacy in abdominal aortic aneurysm

2026-03-13

Abstract excerpt

<title>Abstract</title> <p>Restricted by high shear stress and the arterial endothelial barrier, effective delivery of anti-inflammatory drugs into the aortic media remains a major challenge. We found that the inflammatory microenvironment in the medial layer of human abdominal aortic aneurysm (AAA) tissues was closely associated with aberrant activation of the STING pathway. To enhance transendothelial delivery...

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Literature Corpus work: d2b495d3-f28d-5fe0-bffc-8644120a3594
DOI: 10.21203/rs.3.rs-9012405/v1

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