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Article

Netrin-1 Monoclonal Antibody-Functionalized Nanoparticle Loaded with Metformin Prevents the Progression of Abdominal Aortic Aneurysms.

International journal of nanomedicine - 1 Jan 2023

Zhang Zhiwei, Zhuang Jiawei, Sun Daohan, Ding Qingwei, Zheng Hui, Li Haixiang, Zhang Xiaoyu, Du Yaming, Ma Teng, Meng Qingyou

Abstract excerpt

Background: Abdominal aortic aneurysms (AAAs) are a global health and economic burden. Therapeutic strategies to inhibit the progression of AAAs are currently lacking. Recently, the therapeutic effect of metformin on aneurysms has attracted considerable interest. However, the unfavorable pharmacokinetic properties of metformin limit its feasibility for AAA treatment. Methods and Results: We constructed a...

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Identifiers

PMID: 36777816
DOI: 10.2147/IJN.S400993
PMCID: PMC9912973

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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