Article

Inhibition of CD40-TRAF6 signaling protects against aneurysm development and progression

2023-03-25

Abstract excerpt

<h4>Objective</h4> Inflammation is a critical process during the progressive development and complication of abdominal aortic aneurysm. The co-stimulatory dyad CD40-CD40L is a major driver of inflammation and modulates immune responses. This study evaluates the potential of a small molecule inhibitor, which blocks the interaction between CD40 and tumor necrosis factor (TNF) receptor-associated factor (TRAF)-6, re...

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Literature Corpus work: 4a504f1a-ccc8-5bc1-826d-fb31e2ff94db
DOI: 10.1101/2023.03.24.534110

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