Article

Inhibition of MLKL impairs abdominal aortic aneurysm development by attenuating smooth muscle cell necroptosis

2022-11-24

Abstract excerpt

<h4>Background</h4> Receptor-interacting serine/threonine-protein kinase 1 and 3 (RIPK1 and RIPK3) dependent cell death has been identified as a crucial mediator of abdominal aortic aneurysm (AAA) development. RIPK3 mediates phosphorylation of Mixed lineage kinase domain like pseudokinase (MLKL) thereby inducing its oligomerization and translocation to the cell membrane. Given the dual role of RIPKs being involve...

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Literature Corpus work: 85f8b9cc-37b0-57a2-b64e-aa9d19044d1e
DOI: 10.1101/2022.11.24.517638

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