Article

Loss of MLKL impairs abdominal aortic aneurysm development by attenuating smooth muscle cell necroptosis

2025-07-09

Abstract excerpt

<title>Abstract</title> <p>Abdominal aortic aneurysm (AAA) is a life-threatening condition characterized by chronic vascular inflammation and progressive aortic wall deteriorations. MLKL-driven necroptosis, a highly inflammatory form of cell death, has been implicated in several cardiovascular pathologies; however, its role in AAA remains incompletely understood. Using the aortic elastase-perfusion model, we inve...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2407fe94-c4f0-5226-973e-8be76b876a99
DOI: 10.21203/rs.3.rs-6881818/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Loss of MLKL impairs abdominal aortic aneurysm development by attenuating smooth muscle cell necroptosisDOI 10.21203/rs.3.rs-6881818/v1Read

Inhibition of MLKL impairs abdominal aortic aneurysm development by attenuating smooth muscle cell necroptosisSemantic proximity Read

Pathophysiology of abdominal aortic aneurysms: insights from the elastase-induced model in mice with different genetic backgrounds.Semantic proximity Read

Pharmacologic Inhibition of Ferroptosis Attenuates Experimental Abdominal Aortic Aneurysm FormationSemantic proximity Read

Cellular, Molecular and Clinical Aspects of Aortic Aneurysm-Vascular Physiology and Pathophysiology.Semantic proximity Read

Single-cell RNA sequencing identifies an Il1rn+/Trem1+ macrophage subpopulation as a cellular target for mitigating the progression of thoracic aortic aneurysm and dissectionSemantic proximity Read

Neutrophil Proteases Promote Experimental Abdominal Aortic Aneurysm via Extracellular Trap Release and Plasmacytoid Dendritic Cell Activation.Semantic proximity Read

Single-Cell RNA Sequencing Deconstructs the Distribution of Immune Cells Within Abdominal Aortic Aneurysms in MiceSemantic proximity Read

Inflammatory cell phenotypes in AAAs: their role and potential as targets for therapy.Semantic proximity Read

Endothelium- and Fibroblast-Derived C-Type Natriuretic Peptide Prevents the Development and Progression of Aortic Aneurysm.Semantic proximity Read

Pathogenesis of Abdominal Aortic Aneurysms: MicroRNAs, Proteases, Genetic AssociationsSemantic proximity Read

Extra- and Intraluminal Elastase Induce Morphologically Distinct Abdominal Aortic Aneurysms in Mice and Thus Represent Specific Subtypes of Human Disease.Semantic proximity Read

Inhibition or deletion of angiotensin II type 1 receptor suppresses elastase-induced experimental abdominal aortic aneurysms.Semantic proximity Read