Article

Systemic delivery of murine SOD2 mRNA to experimental abdominal aortic aneurysm mitigates expansion and rupture

2024-06-18

Abstract excerpt

<h4>Background</h4> Oxidative stress is implicated in the pathogenesis and progression of abdominal aortic aneurysm (AAA). Antioxidant delivery as a therapeutic for AAA is of substantial interest although clinical translation of antioxidant therapy has met with significant challenges due to limitations in achieving sufficient antioxidant levels at the site of AAA. We posit that nanoparticle-based approaches hold...

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Literature Corpus work: c815ac88-dbad-5c70-9b70-c126c2097e85
DOI: 10.1101/2024.06.17.599454

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