Article

Proteome profiling of cerebrospinal fluid using machine learning shows a unique protein signature associated with APOE4 genotype

2024-04-22

Abstract excerpt

<h4>INTRODUCTION</h4> Proteome changes associated with APOE4 variant carriage that are independent of Alzheimer’s disease (AD) pathology and diagnosis are unknown. This study investigated APOE4 proteome changes in people with AD, mild cognitive impairment, and no impairment. <h4>METHODS</h4> Clinical, APOE genotype, and cerebrospinal fluid (CSF) proteome and AD biomarker data was sourced from the Alzheimer’s Dis...

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Literature Corpus work: b6e23642-6c9c-561e-8053-a134cce282e3
DOI: 10.1101/2024.04.18.590160

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