Article

Plasma proteomics of <i>APOE</i> genotype: age-specific analyses in UK population-based cohorts

2026-04-17

Abstract excerpt

<h4>Background</h4> The apolipoprotein E ( APOE ) locus is the strongest genetic risk factor for late-onset Alzheimer’s disease (AD). Variation in APOE isoforms is known to have diverse pleiotropic effects on circulating lipids and other metabolites, but effects on the circulating proteome across the life course are not well characterised. We investigated the specific effects of APOE ε4 and APOE ε2 carriage o...

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Literature Corpus work: 3c1a92ec-31c9-567e-9093-25dadd024620
DOI: 10.64898/2026.04.16.26351010

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