Article

Evolutionary Loss of Inflammasomes in Carnivores to Facilitate Carriage of Zoonotic Infections

2021-02-02

Abstract excerpt

Zoonotic infections, such as COVID-19, reside in animal hosts before jumping species to humans. The Carnivora, like mink, carry many zoonoses yet how diversity in host immune genes across species impact upon pathogen carriage are poorly understood. Here we describe a progressive evolutionary downregulation of pathogen sensing inflammasome pathways in Carnivora. This includes the loss of nucleotide-oligomerisati...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d2472039-b3d7-52cc-a8d0-59572c7365fd
DOI: 10.2139/ssrn.3778331

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Evolutionary Loss of Inflammasomes in Carnivores to Facilitate Carriage of Zoonotic InfectionsDOI 10.2139/ssrn.3778331Read

Evolutionary loss of inflammasomes in the Carnivora and implications for the carriage of zoonotic infectionsSemantic proximity Read

Evolutionary loss of inflammasomes in carnivores to facilitate carriage of zoonotic infectionsSemantic proximity Read

Inflammasomes in Teleosts: Structures and Mechanisms That Induce Pyroptosis during Bacterial InfectionSemantic proximity Read

Bat adaptations in inflammation and cell death regulation contribute to viral toleranceSemantic proximity Read

Convergent Losses of TLR5 Suggest Altered Extracellular Flagellin Detection in Four Mammalian LineagesSemantic proximity Read

Evolutionary dynamics of pro-inflammatory caspases in primates and rodentsSemantic proximity Read

Evolutionary Dynamics of Proinflammatory Caspases in Primates and RodentsSemantic proximity Read

Convergent losses of <i>TLR5</i> suggest altered extracellular flagellin detection in four mammalian lineagesSemantic proximity Read

Tripping the wire: sensing of viral protease activity by CARD8 and NLRP1 inflammasomesSemantic proximity Read

Host-specific sensing of coronaviruses and picornaviruses by the CARD8 inflammasomeSemantic proximity Read

Lyssavirus matrix protein inhibits NLRP3 inflammasome assembly by binding to NLRP3Semantic proximity Read

NLRP11 promotes non-canonical inflammasome activation in human macrophages by enhancing caspase-4 recognition of cytosolic lipopolysaccharideSemantic proximity Read