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Host-specific sensing of coronaviruses and picornaviruses by the CARD8 inflammasome

8 Jun 2023

Abstract excerpt

Hosts have evolved diverse strategies to respond to microbial infections, including the detection of pathogen-encoded proteases by inflammasome-forming sensors such as NLRP1 and CARD8. Here, we find that the 3CL protease (3CLpro) encoded by diverse coronaviruses, including Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), cleaves a rapidly evolving region of human CARD8 and activates a robust...

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PMID: 37289745
DOI: 10.1371/journal.pbio.3002144

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