Article

Convergent losses of <i>TLR5</i> suggest altered extracellular flagellin detection in four mammalian lineages

2020-02-25

Abstract excerpt

Toll-like receptors (TLRs) play an important role for the innate immune system by detecting pathogen-associated molecular patterns. TLR5 encodes the major extracellular receptor for bacterial flagellin and frequently evolves under positive selection, consistent with coevolutionary arms races between the host and pathogens. Furthermore, TLR5 is inactivated in several vertebrates and a TLR5 stop codon polymorphis...

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Literature Corpus work: 7b2038b1-649c-546c-80bd-5edd565ad8f7
DOI: 10.1101/2020.02.23.962035

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