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Article

NLRP11 promotes non-canonical inflammasome activation in human macrophages by enhancing caspase-4 recognition of cytosolic lipopolysaccharide

2026-02-04

Abstract excerpt

Innate immune detection of Gram-negative bacteria depends on sensing of cytosolic lipopolysaccharide (cLPS) by the non-canonical inflammasome, mediated in humans by NLRP11 and caspase-4 (CASP4). Activation of this pathway in human macrophages triggers gasdermin-D activation and pyroptotic cell death. Although CASP4 directly binds LPS in vitro, additional host factors are required for efficient activation in vivo....

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Literature Corpus work
cad0dabe-9b30-5e1b-8ae3-098b93d27762
DOI
10.64898/2026.02.02.703338
Open publication

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