Article

Evolutionary loss of inflammasomes in carnivores to facilitate carriage of zoonotic infections

2020-12-07

Abstract excerpt

<h4>Summary</h4> Zoonotic infections, such as COVID-19, reside in animal hosts before jumping species to humans. The Carnivora, like mink, carry many zoonoses yet how diversity in host immune genes across species impact upon pathogen carriage are poorly understood. Here we describe a progressive evolutionary downregulation of pathogen sensing inflammasome pathways in Carnivora. This includes the loss of nucleotid...

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Literature Corpus work: 002afef0-71d3-5276-b4bc-6ac8f3bbdbe6
DOI: 10.1101/2020.12.07.398529

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