Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tripping the wire: sensing of viral protease activity by CARD8 and NLRP1 inflammasomes

11 Jun 2023

Abstract excerpt

Host innate immune sensors are vital for the initial detection of pathogen infection. Such sensors thus need to constantly adapt in escalating evolutionary arms races with pathogens. Recently, two inflammasome-forming proteins, CARD8 and NLRP1, have emerged as innate immune sensors for the enzymatic activity of virus-encoded proteases. When cleaved within a rapidly evolving 'tripwire' region, CARD8 and NLRP1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Inflammasome and immune disorders
Share to interferon and immune responses
Share to Kawasaki Disease and Coronary Complications

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37311351
DOI: 10.1016/j.coi.2023.102354

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tripping the wire: sensing of viral protease activity by CARD8 and NLRP1 inflammasomesPMID 37311351Read ↗

CARD8 inflammasome mediates pyroptosis of HIV-1-infected cells by sensing viral protease activitySemantic proximity Read ↗

Host-specific sensing of coronaviruses and picornaviruses by the CARD8 inflammasomeSemantic proximity Read ↗

Running With Scissors: Evolutionary Conflicts Between Viral Proteases and the Host Immune SystemSemantic proximity Read ↗

NLRP3 Inflammasome—A Key Player in Antiviral ResponsesSemantic proximity Read ↗

Direct cleavage of human NLRP1 by enteroviral 3C protease triggers inflammasome activation in airway epitheliumSemantic proximity Read ↗

Evolution of a Pyroptosis-Apoptosis crosstalk drives non-canonical inflammasome signallingSemantic proximity Read ↗

Human NLRP1: From the shadows to center stageSemantic proximity Read ↗

Inflammasome activation and assembly at a glanceSemantic proximity Read ↗

Evasion of CARD8 activation during HIV-1 assembly.Semantic proximity Read ↗

The NAIP/NLRC4 inflammasomes.Semantic proximity Read ↗

Inflammasome control of viral infectionSemantic proximity Read ↗

Evasion of CARD8 Activation During HIV-1 AssemblySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.