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Convergent Losses of TLR5 Suggest Altered Extracellular Flagellin Detection in Four Mammalian Lineages

3 Mar 2020

Abstract excerpt

Toll-like receptors (TLRs) play an important role for the innate immune system by detecting pathogen-associated molecular patterns. TLR5 encodes the major extracellular receptor for bacterial flagellin and frequently evolves under positive selection, consistent with coevolutionary arms races between the host and pathogens. Furthermore, TLR5 is inactivated in several vertebrates and a TLR5 stop codon polymorphism...

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PMID: 32145026
DOI: 10.1093/molbev/msaa058

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Convergent Losses of TLR5 Suggest Altered Extracellular Flagellin Detection in Four Mammalian LineagesPMID 32145026Read ↗

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