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Evolutionary loss of inflammasomes in the Carnivora and implications for the carriage of zoonotic infections

1 Aug 2021

Abstract excerpt

Zoonotic pathogens, such as COVID-19, reside in animal hosts before jumping species to infect humans. The Carnivora, like mink, carry many zoonoses, yet how diversity in host immune genes across species affect pathogen carriage is poorly understood. Here, we describe a progressive evolutionary downregulation of pathogen-sensing inflammasome pathways in Carnivora. This includes the loss of...

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PMID: 34433041
DOI: 10.1016/j.celrep.2021.109614

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