Article

Tau oligomer heterogeneity and associated protein profile in slowly versus rapidly progressive Alzheimer’s disease

2025-12-13

Abstract excerpt

Rapidly progressive Alzheimer’s disease (rpAD) is a rare but devastating clinical variant characterized by abrupt cognitive decline, yet the molecular features underlying this phenotype remain unknown. Tau oligomers (TauO) are key mediators of tau toxicity, but whether their biochemical properties differ across AD subtypes has not been examined in human brain. We isolated endogenous TauO from frontal cortex of wel...

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Literature Corpus work: d22401cb-f8f1-567b-9b30-9af5c448f988
DOI: 10.64898/2025.12.10.693456

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