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Article

Oligomeric amyloid-β induces early and widespread changes to the proteome in human iPSC-derived neurons.

Scientific reports - 16 Apr 2020

Sackmann Christopher, Hallbeck Martin

Abstract excerpt

Alzheimer's disease (AD) is the most common form of dementia globally and is characterized by aberrant accumulations of amyloid-beta (Aβ) and tau proteins. Oligomeric forms of these proteins are believed to be most relevant to disease progression, with oligomeric amyloid-β (oAβ) particularly implicated in AD. oAβ pathology spreads among interconnected brain regions, but how oAβ induces pathology in these...

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Identifiers

PMID: 32300132
DOI: 10.1038/s41598-020-63398-6
PMCID: PMC7162932

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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