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Article

Proteomic determination of widespread detergent-insolubility including Abeta but not tau early in the pathogenesis of Alzheimer's disease.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Nov 2005

Woltjer Randall L, Cimino P J, Boutté Angela M, Schantz Aimee M, Montine Kathleen S, Larson Eric B, Bird Thomas, Quinn Joseph F, Zhang Jing, Montine Thomas J

Abstract excerpt

Biochemical characterization of the major detergent-insoluble proteins that comprise hallmark histopathologic lesions initiated the molecular era of Alzheimer's disease (AD) research. Here, we reinvestigated detergent-insoluble proteins in AD using modern proteomic techniques. Using liquid chromatography (LC)-mass spectrometry (MS)-MS-based proteomics, we robustly identified 125 proteins in the...

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Identifiers

PMID: 16129700
DOI: 10.1096/fj.05-4263fje

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PSEN1
PSEN2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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