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Proteomic Insight Into Alzheimer's Disease Pathogenesis Pathways

10 Jan 2025

Abstract excerpt

Alzheimer's disease (AD) is a leading cause of dementia, but the pathogenesis mechanism is still elusive. Advances in proteomics have uncovered key molecular mechanisms underlying AD, revealing a complex network of dysregulated pathways, including amyloid metabolism, tau pathology, apolipoprotein E (APOE), protein degradation, neuroinflammation, RNA splicing, metabolic dysregulation, and cognitive resilience....

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PMID: 39791267
DOI: 10.1002/pmic.202400298

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