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Proteomic landscape of Alzheimer’s Disease: novel insights into pathogenesis and biomarker discovery

12 Aug 2021

Abstract excerpt

Mass spectrometry-based proteomics empowers deep profiling of proteome and protein posttranslational modifications (PTMs) in Alzheimer's disease (AD). Here we review the advances and limitations in historic and recent AD proteomic research. Complementary to genetic mapping, proteomic studies not only validate canonical amyloid and tau pathways, but also uncover novel components in broad protein networks, such as...

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PMID: 34384464
DOI: 10.1186/s13024-021-00474-z

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