Article
Pleiotropy-robust Mendelian randomization.
International journal of epidemiology - 1 Aug 2018
van Kippersluis Hans, Rietveld Cornelius A
Abstract excerpt
Background: The potential of Mendelian randomization studies is rapidly expanding due to: (i) the growing power of genome-wide association study (GWAS) meta-analyses to detect genetic variants associated with several exposures; and (ii) the increasing availability of these genetic variants in large-scale surveys. However, without a proper biological understanding of the pleiotropic working of genetic variants, a...
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