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Article

Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases.

Nature genetics - 1 May 2018

Verbanck Marie, Chen Chia-Yen, Neale Benjamin, Do Ron

Abstract excerpt

Horizontal pleiotropy occurs when the variant has an effect on disease outside of its effect on the exposure in Mendelian randomization (MR). Violation of the 'no horizontal pleiotropy' assumption can cause severe bias in MR. We developed the Mendelian randomization pleiotropy residual sum and outlier (MR-PRESSO) test to identify horizontal pleiotropic outliers in multi-instrument summary-level MR testing. We...

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Identifiers

PMID: 29686387
DOI: 10.1038/s41588-018-0099-7
PMCID: PMC6083837

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