Article
Exploiting horizontal pleiotropy to search for causal pathways within a Mendelian randomization framework.
Nature communications - 21 Feb 2020
Cho Yoonsu, Haycock Philip C, Sanderson Eleanor, Gaunt Tom R, Zheng Jie, Morris Andrew P, Davey Smith George, Hemani Gibran
Abstract excerpt
In Mendelian randomization (MR) analysis, variants that exert horizontal pleiotropy are typically treated as a nuisance. However, they could be valuable in identifying alternative pathways to the traits under investigation. Here, we develop MR-TRYX, a framework that exploits horizontal pleiotropy to discover putative risk factors for disease. We begin by detecting outliers in a single exposure-outcome MR...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.