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Article

Weak and pleiotropy robust sex-stratified Mendelian randomization in the one sample and two sample settings.

Genetic epidemiology - 1 Mar 2023

Karageorgiou Vasilios, Tyrrell Jess, Mckinley Trevelyan J, Bowden Jack

Abstract excerpt

BACKGROUND: Mendelian randomization (MR) leverages genetic data as an instrumental variable to provide estimates for the causal effect of an exposure X on a health outcome Y that is robust to confounding. Unfortunately, horizontal pleiotropy-the direct association of a genetic variant with multiple phenotypes-is highly prevalent and can easily render a genetic variant an invalid instrument. METHODS: Building on...

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PMID: 36682072
DOI: 10.1002/gepi.22512

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