Article
Mendelian randomization incorporating uncertainty about pleiotropy.
Statistics in medicine - 20 Dec 2017
Thompson John R, Minelli Cosetta, Bowden Jack, Del Greco Fabiola M, Gill Dipender, Jones Elinor M, Shapland Chin Yang, Sheehan Nuala A
Abstract excerpt
Mendelian randomization (MR) requires strong assumptions about the genetic instruments, of which the most difficult to justify relate to pleiotropy. In a two-sample MR, different methods of analysis are available if we are able to assume, M1 : no pleiotropy (fixed effects meta-analysis), M2 : that there may be pleiotropy but that the average pleiotropic effect is zero (random effects meta-analysis), and M3 : that...
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