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Article

MRBEE: A bias-corrected multivariable Mendelian randomization method.

HGG advances - 18 Jul 2024

Lorincz-Comi Noah, Yang Yihe, Li Gen, Zhu Xiaofeng

Abstract excerpt

Mendelian randomization (MR) is an instrumental variable approach used to infer causal relationships between exposures and outcomes, which is becoming increasingly popular because of its ability to handle summary statistics from genome-wide association studies. However, existing MR approaches often suffer the bias from weak instrumental variables, horizontal pleiotropy and sample overlap. We introduce MRBEE (MR...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38582968
DOI: 10.1016/j.xhgg.2024.100290
PMCID: PMC11053334

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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