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Article

Detecting pleiotropy in Mendelian randomisation studies with summary data and a continuous outcome.

Statistics in medicine - 20 Sept 2015

Greco M Fabiola Del, Minelli Cosetta, Sheehan Nuala A, Thompson John R

Abstract excerpt

Mendelian randomisation (MR) estimates causal effects of modifiable phenotypes on an outcome by using genetic variants as instrumental variables, but its validity relies on the assumption of no pleiotropy, that is, genes influence the outcome only through the given phenotype. Excluding pleiotropy is difficult, but the use of multiple instruments can indirectly address the issue: if all genes represent valid...

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PMID: 25950993
DOI: 10.1002/sim.6522

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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