Article

TPX2 Induces Mitotic Survival via BCL2L1 Induction Through YAP1 Protein Stabilization in Human Embryonic Stem Cells

2021-06-28

Abstract excerpt

<title>Abstract</title> <p>Genetic alterations have been reported in most human embryonic stem cells (hESCs) for decades. ‘Survival advantage,’ a typical trait acquired during long-term <italic>in vitro</italic> culture, results from induction of <italic>BCL2L1 </italic>upon frequent copy number variation (CNV) at locus 20q11.21 and is one of the strongest candidates associated with genetic alteration via escape...

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Literature Corpus work: d1c463fc-715b-556e-aa87-8f51064cea31
DOI: 10.21203/rs.3.rs-626430/v1

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