Article

UBQLN1 functions in telomere maintenance and differentiation of human embryonic stem cells

2024-01-31

Abstract excerpt

<title>Abstract</title> <p>Background Telomeres consist of repetitive DNA sequences at the chromosome ends to protect chromosomal stability, and primarily maintained by telomerase or occasionally by alternative telomere lengthening of telomeres (ALT) through recombination-based mechanisms. Additional mechanisms that may regulate telomere maintenance remain to be explored. Simultaneous measurement of telomere len...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fb467e3f-a91e-5678-af7f-93412792d26e
DOI: 10.21203/rs.3.rs-3877910/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

UBQLN1 functions in telomere maintenance and differentiation of human embryonic stem cellsDOI 10.21203/rs.3.rs-3877910/v1Read

Telomere heterogeneity linked to metabolism and pluripotency state revealed by simultaneous analysis of telomere length and RNA-seq in the same human embryonic stem cellSemantic proximity Read

<i>TelNet</i> - a database for human and yeast genes involved in telomere maintenanceSemantic proximity Read

Telomere-dependent and telomere-independent roles of RAP1 in regulating human stem cell homeostasisSemantic proximity Read

TelNet - a database for human and yeast genes involved in telomere maintenanceSemantic proximity Read

Two separation-of-function isoforms of human TPP1 and a novel intragenic noncoding RNA dictate telomerase regulation in somatic and germ cellsSemantic proximity Read

ZBTB48 is both a vertebrate telomere‐binding protein and a transcriptional activatorSemantic proximity Read

Distinct characteristics of two types of alternative lengthening of telomeres in mouse embryonic stem cells.Semantic proximity Read

TIN2 deficiency leads to ALT-associated phenotypes and differentiation defects in embryonic stem cells.Semantic proximity Read

Functional characterization of RNA profiles in processing bodies of human embryonic stem cells and mesodermal cellsSemantic proximity Read

The evolutionarily conserved factor Sus1/ENY2 plays a role in telomere length maintenance.Semantic proximity Read

TPX2 Induces Mitotic Survival via BCL2L1 Induction Through YAP1 Protein Stabilization in Human Embryonic Stem CellsSemantic proximity Read

Systematic analysis of human telomeric dysfunction using inducible telosome/shelterin CRISPR/Cas9 knockout cellsSemantic proximity Read