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Article

BCL-XL mediates the strong selective advantage of a 20q11.21 amplification commonly found in human embryonic stem cell cultures.

Stem cell reports - 1 Jan 2013

Avery Stuart, Hirst Adam J, Baker Duncan, Lim Chin Yan, Alagaratnam Sharmini, Skotheim Rolf I, Lothe Ragnhild A, Pera Martin F, Colman Alan, Robson Paul, Andrews Peter W, Knowles Barbara B

Abstract excerpt

Human embryonic stem cells (hESCs) regularly acquire nonrandom genomic aberrations during culture, raising concerns about their safe therapeutic application. The International Stem Cell Initiative identified a copy number variant (CNV) amplification of chromosome 20q11.21 in 25% of hESC lines displaying a normal karyotype. By comparing four cell lines paired for the presence or absence of this CNV, we show that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24286026
DOI: 10.1016/j.stemcr.2013.10.005
PMCID: PMC3841249

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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