Article

Increases in <i>BCL2L1</i> and <i>ID1</i> dosage synergistically drive fate bias and competitive advantage in human pluripotent stem cells

2026-03-29

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Gains of chromosome 20q11.21 are among the most common culture-acquired abnormalities in human pluripotent stem cells (hPSC), conferring a well-defined survival advantage while altering differentiation capacity. However, it remains unclear whether this advantage persists during differentiation, how the aneuploidy alters ectodermal and retinal pigment epithelium (RPE) lineage...

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Literature Corpus work: 7d0ef238-553e-5a5e-8a10-b51cb1821d4a
DOI: 10.64898/2026.03.26.714405

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