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Mitotic Stress and Chromosomal Instability in Cancer: The Case for TPX2

1 Nov 2012

Abstract excerpt

Cell cycle deregulation is a common motif in human cancer, and multiple therapeutic strategies are aimed to prevent tumor cell proliferation. Whereas most current therapies are designed to arrest cell cycle progression either in G1/S or in mitosis, new proposals include targeting the intrinsic chromosomal instability (CIN, an increased rate of gain or losses of chromosomes during cell division) or aneuploidy (a...

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PMID: 23634259
DOI: 10.1177/1947601912473306

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