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Characterizing the innate and adaptive responses of immunized mice to <i>Bordetella pertussis</i> infection using <i>in vivo</i> imaging and transcriptomic analysis

2019-06-18

Abstract excerpt

Bordetella pertussis ( B. pertussis ) is the causative agent of pertussis (whooping cough). Since the 1990s, pertussis has re-emerged in the United States despite an estimated 95% vaccine coverage. Our goal was to characterize neutrophil responses and gene expression profiles of murine lungs in the context of vaccination and B. pertussis challenge. We utilized a bioluminescent neutrophil mouse model (NECre luc)...

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Literature Corpus work
d198e9b6-9415-5c2c-b8cc-a62e7a21870e
DOI
10.1101/674408
Open publication

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Characterizing the innate and adaptive responses of immunized mice to <i>Bordetella pertussis</i> infection using <i>in vivo</i> imaging and transcriptomic analysisDOI 10.1101/674408
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