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Article

Age-Dependent Effects of Type I and Type III IFNs in the Pathogenesis of Bordetella pertussis Infection and Disease.

Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 2020

Ardanuy Jeremy, Scanlon Karen, Skerry Ciaran, Fuchs Serge Y, Carbonetti Nicholas H

Abstract excerpt

Type I and III IFNs play diverse roles in bacterial infections, being protective for some but deleterious for others. Using RNA-sequencing transcriptomics we investigated lung gene expression responses to Bordetella pertussis infection in adult mice, revealing that type I and III IFN pathways may play an important role in promoting inflammatory responses. In B. pertussis-infected mice, lung type I/III IFN...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32152071
DOI: 10.4049/jimmunol.1900912
PMCID: PMC7141952

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