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Pre-existing antibodies predict protection while mucosal inflammation correlates with symptomatic <i>Bordetella pertussis</i> infection

2026-07-09

Abstract excerpt

Despite decades of widespread vaccination, whooping cough caused by Bordetella pertussis (Bp) continues to circulate globally. To define correlates of protection and mechanisms underlying symptom development, we characterized systemic and mucosal immune responses in a controlled human infection model of Bp ( NCT05136599 ). Healthy vaccinated adults were intranasally challenged with escalating Bp doses and classi...

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Literature Corpus work
d1caa1fe-2247-52c5-8015-f4f8c9b4da59
DOI
10.64898/2026.06.26.26356067
Open publication

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