Article
The transcriptional responses of respiratory epithelial cells to <i>Bordetella pertussis</i> reveal host defensive and pathogen counter-defensive strategies
21 Nov 2000
Abstract excerpt
Bordetella pertussis, the causative agent of whooping cough, has many well-studied virulence factors and a characteristic clinical presentation. Despite this information, it is not clear how B. pertussis interaction with host cells leads to disease. In this study, we examined the interaction of B. pertussis with a human bronchial epithelial cell line (BEAS-2B) and measured host transcriptional profiles by using...
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