Article

Early Innate Immune Signatures Imprint Clinical Outcomes of <i>Bordetella pertussis</i> Challenge in a Controlled Human Infection Model

2026-06-26

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Despite widespread vaccination, Bordetella pertussis ( B. pertussis ) continues to re-emerge globally, highlighting critical gaps in our understanding of vaccine-induced protective immunity. Controlled human infection models (CHIMs) offer a powerful platform to interrogate host-pathogen interactions in vivo , define correlates and mechanisms of protection, and inform next...

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Literature Corpus work: 3a71c836-8c23-5ec1-abb6-d8e54393bdfe
DOI: 10.64898/2026.06.24.26356444

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