Systems Biology-Based Assessment of Immune Responses to Whole Cell and Acellular Pertussis Vaccines: Rationale, Methodology and Enrollment Procedures for Omics Workflows

Abstract excerpt

<title>Abstract</title> <p>Given the local and systemic adverse reactions associated with whole cell pertussis vaccines combined with diphtheria and tetanus toxoids (DTP), acellular pertussis vaccines combined with the same toxoids (DTaP) were developed in the 1990s. In comparison to DTP, DTaP vaccines demonstrated reduced reactogenicity and equivalent or improved immunogenicity and efficacy. However, there has b...

Topics

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• Immune responses and vaccinations
• Immunotherapy and Immune Responses
• Influenza Virus Research Studies
• Respiratory viral infections research
• Salivary Gland Disorders and Functions
• SARS-CoV-2 and COVID-19 Research
• T-cell and B-cell Immunology
• vaccines and immunoinformatics approaches

Identifiers and source

Literature Corpus work

f515e73d-dfc7-57b1-aca1-268846a08527

DOI

10.21203/rs.3.rs-5433896/v1